This report describes eight frontier large language model (LLM) agents on their ability to design DNA segments, interact with a benchtop DNA synthesizer, and generate laboratory protocols. These are dual-use tasks, explored as potential technical bottlenecks to a malicious actor building a viral pathogen that could be weaponized. Performance varied among the models, but all tested LLMs designed biologically coherent DNA segments in some attempts.
2026-W06
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